Week 16 NFL Picks: Over/Under Projections, Odds Advice and Line Spreads

On first pass, it seems like NFL bettors have a rather simple avenue to coming out ahead in Week 16.

This, of course, is the best-case scenario as the season winds down. Bettors have two weeks to either build on a playoff bankroll or recoup losses before the majority of the league joins bettors in watching from the couch.

These early-week lines seem to offer plenty in the way of openings, though shifts will happen fast as a result. It helps that the league itself doesn’t have too many 50-50 games on tap in Week 16, with most seeming to boast a clear-cut winner one way or the other. 

Here’s a look at the full list of odds and a few notable early picks to make. 

NFL Week 16 Odds

Odds according to OddsShark.

Tennessee (-4.5) at Jacksonville

When in doubt, pick against the Jacksonville Jaguars. Or better yet, when in doubt this year, roll with the Tennessee Titans.

The Titans are easily one of the NFL’s best teams, regardless of whether the general public has caught on to the factoid. Bettors understand it more than most seeing as the Titans have won four of their last five, taking down contenders such as the Green Bay Packers and Denver Broncos, not to mention doing the almost impossible and winning in Kansas City against the Chiefs.

Good luck finding a weakness for the Titans. Marcus Mariota has 25 touchdowns to nine interceptions, DeMarco Murray and Derrick Henry have combined for more than 1,600 rushing yards and 13 scores, and the defense only allows 23.1 points per game with 34 sacks and 12 interceptions.

Compare that to the Jaguars, a two-win team without a victory since Week 6. The team sits in a limbo of sorts after canning former head coach Gus Bradley. This won’t do much to fix Blake Bortles under center, nor a rushing attack without a rusher sitting on more than 500 yards.

These two met in Week 8, a 36-22 victory for the Titans as Mariota cruised with two touchdowns and both of his backs found room for a score as well. Bortles went for three touchdowns, but against a soft defense after …

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