Pittsburgh Steelers vs. Indianapolis Colts Betting Odds, Analysis, NFL Pick

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Two teams looking to stay in playoff contention will meet Thanksgiving night in Indianapolis, as the Colts (5-5) host the Pittsburgh Steelers (5-5) as home underdogs.

Indianapolis might be without quarterback Andrew Luck due to a concussion, which would take the luster off what would have been a blockbuster matchup opposite Pittsburgh’s Ben Roethlisberger and make the line move even more in the road team’s favor.

Point spread: The Steelers opened as 2.5-point favorites; the total was 53 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

NFL pick, via Odds Shark computer: 27.8-21.6 Colts (NFL picks on every game)

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Why the Steelers can cover the spread

The Steelers have dominated the Colts over the past three decades, winning 13 of the past 15 meetings straight up and covering the spread in 10 of them. The teams have met each of the last two seasons, with …

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