New England Patriots vs. Buffalo Bills Betting Odds, Analysis, NFL Pick

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The New England Patriots (6-1) will get a chance to avenge their only loss of the season when they visit the Buffalo Bills (4-3) on Sunday as solid road favorites.

The Patriots have gone a perfect 3-0 straight up and against the spread since losing at home to the Bills without quarterback Tom Brady, who has been nothing short of outstanding in his return from a four-game suspension. 

Point spread: The Patriots opened as 4.5-point favorites; the total was 47 early in the week, according to sportsbooks monitored by Odds Shark (line updates and matchup report).

NFL pick, via Odds Shark computer: 27.7-20.4 Patriots (NFL picks on every game)

   

Why the Patriots can cover the spread

New England is an unreal 11-1 SU and 9-2-1 against the spread in its last 12 trips to Buffalo, according to the Odds Shark NFL Database, and this time Brady will be there to go for the split of the regular-season series.

As much as Bills head coach Rex Ryan deserves credit for leading his team to a shutout victory on the road in the last meeting, the Patriots were playing a …

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