NFL Predictions Week 5: Odds, Predictions and Advice for Ideal Underdogs

Those who love a good upset in the NFL have flourished this season.

Upsets offer epic payouts at times, so it makes sense a culture embedded in rooting for the underdog gravitates there—the added rewards are just a bonus. Look at Week 4, as those who decided to roll against the New England Patriots, Detroit Lions, Carolina Panthers and Arizona Cardinals all came out ahead.

For those who didn’t make headway in the bankroll department, Week 5 would be the time to hop aboard the upset train. A casual glance at the slate suggests a few upsets—a deeper dive all but assures it.

Here’s a full look at the schedule and some contests featuring notable underdogs.

NFL Week 5 Odds

Odds courtesy of Odds Shark.

Advice for Ideal Underdogs Arizona (-2.5) at San Francisco

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On the road and likely without their starting quarterback, the aforementioned Cardinals continue to somehow stand as the favorites ahead of Thursday Night Football. 

Now is a good time for bettors to show some faith in the San Francisco 49ers.

The Cardinals took a major loss last week, falling 17-13 to the Los Angeles Rams and making it two losses in a row. In fact, Arizona hasn’t even come close to living up to Super Bowl expectations: Its only win in four attempts came against the Tampa Bay Buccaneers.

To top it all off, Arizona lost quarterback Carson Palmer to a concussion:

Don’t expect Cardinals QB Carson Palmer to play Thursday after taking a hit to the head. In fact, he might be out awhile… pic.twitter.com/tZhDKJR5wa

— Bleacher Report NFL (@BR_NFL) October 4, 2016

So yes, San Francisco looks like a great underdog. Granted, the 49ers have lost three in a row, but the first two games of the skid were road contests against the Panthers and Seattle Seahawks.

Quarterback Blaine Gabbert hasn’t posted inspiring play yet, but running back Carlos Hyde has looked great with 299 yards and five scores on a 4.1 per-carry average.

In the second meeting between these teams last year, San Francisco went down swinging by six points while holding Palmer to 271 yards, with Gabbert throwing for 318 yards and a …

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