NFL Predictions Week 5: Every Game’s Odds, Lines and Score Predictions

Sometimes in the NFL, the outcome of one week’s game doesn’t seem to have much effect on the odds for the next game on the schedule. 

For instance, if you’re the New England Patriots and you have your star quarterback coming back from suspension in Week 5, you can be a 10-point favorite even if you put up zero points on a division rival in Week 4. 

Or, if you’re the Arizona Cardinals and you’ve dropped two games straight, most recently to the Los Angeles Rams, and looked asleep at the wheel while doing so, you still find yourself a two-and-a-half-point favorite over the San Francisco 49ers.  

Let’s take a look at all the other point spreads for Week 5’s slate of games, as well as the safest bet this week and a big gamble, especially if you’re picking straight up. 

Note that the Jacksonville Jaguars, Kansas City Chiefs, New Orleans Saints and Seattle Seahawks have a bye in Week 5.  

Safest Best: New England (-10) over Cleveland

Sure, the Patriots came up with nothing against the Buffalo Bills in Week 4, suffering their first loss of the season as the Bills defeated them 16-0. 

But there’s no reason to believe that the Pats won’t continue their winning ways when quarterback Tom Brady returns in Week 5 to take on the Cleveland Browns. 

Needless to say, Browns coach Hue Jackson isn’t looking forward to that prospect, as Mary Kay Cabot of Cleveland.com shared:

#Browns Hue Jax on facing Tom Brady coming off suspension: “Not fun at all”

— Mary Kay Cabot (@MaryKayCabot) October 3, 2016

Under rookie backup quarterback Jacoby Brissett, New England’s offense looked anemic. The Patriots failed to convert a third down for three quarters of the game and, obviously, failed to find the end zone …

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