NFL Picks Week 4: Expert Predictions, Odds Guide and Over-Under Lines

Nobody can be certain of anything from week to week in the NFL, except that nothing can hurt the New England Patriots and the Cleveland Browns are destined to break their fans’ hearts.

Few could have foreseen the Buffalo Bills putting a stomping on the Arizona Cardinals in Week 3, while presumably no one had the guts to predict the Philadelphia Eagles beating the Pittsburgh Steelers by more than 30 points, with a rookie quarterback at the helm to boot. 

There’s plenty of variance and unpredictability thanks to the NFL’s commitment to parity, but that doesn’t stop people from trying to predict what’s going to happen each week.

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Here’s a look at what some of the experts from around the web are thinking about the week ahead, along with the spread and over-under lines for each contest. 

Note: Picks are all straight up and courtesy of Bleacher Report, CBSSports.com, SB Nation, ESPN.com and FiveThirtyEight. Odds are from Odds Shark and updated as of Thursday at 9 a.m. ET.

Chargers-Saints Should See Plenty of Points

Three games, three season-ending injuries for San Diego Chargers starters. In Week 1, it was wide receiver Keenan Allen. In Week 2, it was running back Danny Woodhead, and Week 3 saw the Chargers lose a close one to the Indianapolis Colts as well as starting inside linebacker Manti Te’o for the season due to a torn Achilles tendon. 

Despite all this suffering, the experts and the odds still like the Chargers at home against the New Orleans Saints. This is because the Saints have a snakebitten secondary that even the hamstrung Chargers should be able to exploit. Philip Rivers has proved himself adept at adjusting to the personnel around him, relying on Travis Benjamin to stretch defenses and Tyrell Williams to keep the chains moving. 

Melvin Gordon didn’t have a great time running the ball against the Colts (16 carries, 35 yards), but he …

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