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Buffalo Bills vs. New England Patriots Betting Odds, Analysis, NFL Pick
- Updated: September 29, 2016
The New England Patriots (3-0) may not yet know who their starting quarterback will be Sunday when they host the Buffalo Bills in an AFC East matchup. But the Patriots are solid home favorites as they try to beat the Bills for the 24th time in 26 meetings with Tom Brady set to return in Week 5.
Point spread: The Patriots opened as four-point favorites; the total was not available early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
NFL pick, via Odds Shark computer: 29.0-12.7 Patriots (NFL picks on every game)
Why the Bills can cover the spread
Buffalo head coach Rex Ryan has enjoyed some success vs. New England in the past, but his current team lost both meetings a year ago by a combined 15 points.
Ryan has joked about the possibility of wide receiver Julian Edelman lining up under center for the Patriots if Jimmy Garoppolo and Jacoby Brissett can’t play, and anybody other than Brady would be good for …
