NFL Predictions Week 3: Picks and Odds Advice for Latest Schedule

In a perfect world, those who wish to play NFL Week 3 lines got a head start against the house.

More often than not, it is easier for bettors to take advantage of early-week lines. There, the house can make slight goofs before adjusting lines later in the week or getting impacted by breaking news.

Luckily for bettors, plenty of solid lines exist this weekend and a quick guide will shine the proper light. Whether it is injuries, a simple mismatch or something more, procrastinators can look like those winners who prepared all week if they know where to search.

NFL Week 3 Odds

Last-Minute Odds to Bet  Arizona (-4.5) at Buffalo

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It isn’t hard to see why bettors may fall in love with the idea of the Buffalo Bills pulling off an upset of the Arizona Cardinals while playing host this weekend.

After all, the Bills have a talented Rex Ryan-led defense, a versatile quarterback in Tyrod Taylor, a great weapon for him to hit in Sammy Watkins and a running back by the name of LeSean McCoy. 

Perspective always helps: The Bills fired former offensive coordinator Greg Roman this week, and while Taylor has three touchdowns to one interception, Watkins has caught all of six passes and McCoy has 117 yards on a 3.8 per-carry average. 

NFL Network’s Ian Rapoport provided some news on Sunday that those with an upset on the mind will want to hear:

#Bills WR Sammy Watkins (foot), who got stepped on in a walk-through this week, is out vs. #AZCardinals, source said.

— Ian Rapoport (@RapSheet) September 25, 2016

Arizona might have to travel, but head coach Bruce Arians boasts the better team. The Cardinals have the Super Bowl on the mind, even after getting upset in Week 1 by the New England Patriots. Last week was a return to form in a 40-7 dismantling of the Tampa Bay Buccaneers in which quarterback Carson Palmer tossed a trio of touchdowns and the defense forced five turnovers. 

It is not hard to see the writing on the wall here. A team, professional or not, doesn’t just implement a new offense after one week while missing …

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