Indianapolis Colts vs. Denver Broncos Betting Odds, Analysis, NFL Pick

The Indianapolis Colts are coming off a disappointing home loss to the Detroit Lions last week and will try to rebound on Sunday as road underdogs against the defending Super Bowl champion Denver Broncos.

The Colts have started 0-2 each of the previous two seasons, bouncing back to make the AFC Championship Game two years ago but then missing the playoffs altogether in 2015 due to injuries to quarterback Andrew Luck.

Point spread: The Broncos opened as four-point favorites; the total was 44 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

NFL pick, via Odds Shark computer: 27.7-14.6 Broncos (NFL picks on every game)

Why the Colts can cover the spread

This scenario is nothing new for Indianapolis, although the team lost its season opener on the road each of the previous two years. Fortunately for the Colts, they have enjoyed a lot of recent success versus the Broncos, winning eight of the past nine meetings straight up and going a perfect 9-0 against the spread during that stretch, according to the …

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