New England Patriots vs. Arizona Cardinals Betting Odds, Analysis, NFL Pick

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The Arizona Cardinals will try to take advantage of Tom Brady’s absence and win their regular-season opener against the New England Patriots on Sunday night as solid home favorites, with the line tilting heavily in their favor once Brady’s suspension became official.

The Cardinals hope to win their eighth straight game during the month of September by pressuring Brady’s replacement Jimmy Garoppolo in his first career start.

    

Point spread: The Patriots opened as one-point favorites; the total was 51 early in the week, according to sportsbooks monitored by Odds Shark (see line updates and matchup report).

NFL pick, via Odds Shark computer: 27.0-15.0 Cardinals (NFL picks on every game)

     

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Why the Patriots can cover the spread

Garoppolo may not have any previous starts in the NFL, but he was a highly touted second-round pick out of the same school (Eastern Illinois) that produced Mike Shanahan, Sean Payton and Tony Romo. The experience he has gained …

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